Pragmatic comparative effectiveness randomized controlled trials evaluate the effectiveness of one interventions under real-world clinical conditions. The results of ceRCTs are often directly generalizable to everyday clinical practice, providing information critical to decision-making by patients, clinicians, and healthcare policymakers. The PRECIS-2 framework identifies nine domains that serve to score a trial on a continuum between very explanatory to very pragmatic. According to the framework, pragmatic trials may have one or more of the following features: there are fewer eligibility criteria for (...) participants, in an... (shrink)

The format of this book is unusual, especially for a book about linguistics. The book is meant primarily as a research monograph aimed at linguists who have some background in formal semantics, e. g. Montague Grammar. However, I have two other audiences in mind. Linguists who have little or no experience of formal semantics, but who have worked through a basic mathematics for linguists course (e. g. using Wall, 1972, or Partee, 1978), should, perhaps with the help of a sympathetic (...) Montague gramma rian, be able to discover enough of how I have adapted some of the basic ideas in formal semantics to make the developments that I undertake in the rest of the book accessible. Logicians and computer scientists who know about model theoretic semantics and formal systems should be able to glean enough from Chapters I and II about linguistic concerns and techniques to be able to read the remainder of the book, again possibly with the help of a sympathetic Montague grammarian. However, readers should beware. Chapter II is not meant as a general introduction either to formal semantics or to linguistics and while much of the presentation there is going over ground that is already well covered in the literature, the particular formulation and the emphases are very much oriented to the developments to be undertaken later in the book. (shrink)

The ethics of the Flexibility In duty hour Requirements for Surgical Trainees trial have been vehemently debated. Views on the ethics of the FIRST trial range from it being completely unethical to wholly unproblematic. The FIRST trial illustrates the complex ethical challenges posed by cluster randomised trials of policy interventions involving healthcare professionals. In what follows, we have three objectives. First, we critically review the FIRST trial controversy, finding that commentators have failed to sufficiently identify and address many of the (...) relevant ethical issues. The 2012 Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials provides researchers and research ethics committees with specific guidance for the ethical design and conduct of CRTs. Second, we aim to demonstrate how the Ottawa Statement provides much-needed clarity to the ethical issues in the FIRST trial, including: research participant identification; consent requirements; gatekeeper roles; benefit-harm analysis and identification of vulnerable participants. We nonetheless also find that the FIRST trial raises ethical issues not adequately addressed by the Ottawa Statement. Hence, third and finally, we raise important questions requiring further ethical analysis and guidance, including: Does clinical equipoise apply to policy interventions with little or no evidence-base? Do healthcare providers have an obligation to participate in research? Does the power-differential in certain healthcare settings render healthcare providers vulnerable to duress and coercion to participant in research? If so, what safeguards might be implemented to protect providers, while allowing important research to proceed? (shrink)

This is the third edition, with updated notes and appendices, of Cicero's speech defending Caelius Rufus. It gives an insight into the political events of the period, and also helps to reconstruct the 'social background' of Catullus. It is of particular interest to the literary historian.

The MS. tradition of Prudentius is particularly interesting, since in the famous Codex Puteanus we have a MS. dating from the early sixth century—i.e. but little more than a hundred years after the publication of the collected poems in 405. Yet it has only been of late years that due consideration has been given to this ancient Codex, which is the actual MS. corrected by Vettius Mavortius' own hand. Mr. Winstedt has spoken of the neglect which it has suffered for (...) the most part from editors, and also of the similar lack of attention paid even by Dressel to its seventh-century companion at Milan—the Codex Ambrosianus; while, later, J. Bergman shewed himself enthusiastic in its praise. A confirmation is now available of a curious and generally discredited reading in this MS., from that same Arma glossary of ‘saec. viii.-ix’ which bears witness to the readings of a lost Terence MS. of the δ-family, the best minuscule family, older than any extant MS., as I shewed in the April, 1925, number of this journal. At Prud. Apoth. 895 the reading of Puteanus is—Agenitus genitusque deus, pater et patre natus. (shrink)

Of these lines Markland wrote in 1728 ‘patet ignari cuiusdam et barbari interpolatoris esse’; Dr. Trapp in 1735 found them ‘in themselves flat, and improper, and altogether unworthy of Virgil’; ‘in his ipsis miror qui factum sit ut Viri Doctissimi non agnouerint orationis uim et elegantiam’ ; ‘finding in them … all Virgil's usual ease and suavity … [we] hail those verses with joy, and reinstate them in their rightful … position as the commencing verses of the great Roman epic’ (...) ; ‘uersus praeclarissimos iniuria poeta abiudicauerunt editores plerique’. (shrink)

The clear affinity between Quintilian's art-criticism and the comparable portions of Pliny's Natural History has often been remarked. Pliny's principal sources for his chapters on art have long been recognized as going back through Varro to the great third-century critics, Xenocrates of Sicyon and Antigonus of Carystus, the latter of whom worked over Xenocrates' treatise and incorporated new material of his own; an earlier Greek source was Duris of Samos, on whom Antigonus drew for the anecdotic element in his tradition. (...) The careful work of many patient scholars has been successful in disentangling to a considerable extent the characteristic contributions of these and other authorities to Pliny's medley of information. On the other hand, Quintilian's incursion into the same field seems never to have been studied independently, but only incidentally to research on the Plinian sources. The purpose of this paper is to examine Quintilian's contribution afresh; my indebtedness to earlier studies, in particular to those of Robert, will be readily apparent. (shrink)

On Aen. 2. 277 DServius notes ‘non sine ratione etiam hoc de crinibus dolet Aeneas, quia illis maxime Hector commendabatur, adeo ut etiam tonsura ab eo nomen acceperit, sicut Graeci poetae docent.’ Fraenkel showed that the reference in Graeci poetae is to Lycophron , the source of the comment being provided by Eustathius 1276. 29, a scholion on Il. 22. 401 f. He adds a caution against supposing that Servius’ source referred not only to Lycophron but also to other Greek (...) poets, ‘e.g. some Attic comedians’. That such allusions were in fact made in Comedy is proved by Pollux. (shrink)

The MS. tradition of Prudentius is particularly interesting, since in the famous Codex Puteanus we have a MS. dating from the early sixth century—i.e. but little more than a hundred years after the publication of the collected poems in 405. Yet it has only been of late years that due consideration has been given to this ancient Codex, which is the actual MS. corrected by Vettius Mavortius' own hand. Mr. Winstedt has spoken of the neglect which it has suffered for (...) the most part from editors, and also of the similar lack of attention paid even by Dressel to its seventh-century companion at Milan—the Codex Ambrosianus; while, later, J. Bergman shewed himself enthusiastic in its praise . A confirmation is now available of a curious and generally discredited reading in this MS. , from that same Arma glossary of ‘saec. viii.-ix’ which bears witness to the readings of a lost Terence MS. of the δ-family, the best minuscule family, older than any extant MS., as I shewed in the April, 1925, number of this journal. At Prud. Apoth. 895 the reading of Puteanus is— Agenitus genitusque deus, pater et patre natus. (shrink)

Few critics can ever have shown more light-hearted thoughtlessness towards an anxious posterity than Servius in his casual preservation of the ‘Helen-episode’, lacking in our ancient manuscripts of Virgil and primarily extant only in this precarious form. A pity that Servius spoke at all, if he could not tell us more; and to make matters worse, he ignored the lines in his commentary. Aelius Donatus says nothing of them. Tiberius Claudius Donatus passes peacefully in his interpretatio from 2. 566 to (...) 2. 589; his prosy conscientiousness nowhere else allows him to skip so much. The passage so rashly preserved forms an exasperating Tummelplatz for students of Virgil: ‘quadereviridoctiiampridem inter se certarunt semperque, ni fallor, certabunt.’ The purpose of this paper is to suggest that Servius told the truth about the lines, and was not planting a forgery on a credulous world. (shrink)

The essays in this collection honor Professor Ellis Sandoz, Hermann Moyse Jr. Distinguished Professor of Political Science, Louisiana State University, and founding director of the Eric Voegelin Institute for American Renaissance Studies, an institute located at Louisiana State University and devoted to research and publication in the fields of political philosophy, constitutional law, and Voegelin studies. Without the tireless leadership—both academic and economic—of Ellis Sandoz, who was one of Eric Voegelin’s early students and his first American doctoral candidate at the (...) University of Munich, the thirty-four volumes of _The Collected Works of Eric Voegelin _would never have neared completion within only twenty years of Voegelin’s death. The authors of the essays, some of the most respected scholars in the field of political philosophy, hail from Austria, Canada, the Czech Republic, Germany, Ireland, and the United States. They have known Sandoz in a variety of ways: as former students, as beneficiaries of his work on constitutionalism, as fellow participants in the publication of _The Collected Works of Eric Voegelin_, as philosophical colleagues, as participating members of the Eric Voegelin Society, and finally as friends. The essays, each written especially for this volume, are grouped into the disciplines of philosophy, literature, and politics and range widely across these subjects, exploring writers as diverse as Xenophon, Natsume Soseki, Freud, and George Santayana and topics ranging from the leadership style of François Mitterrand and the Velvet Revolution to the nature of the Law and of the Political. _Philosophy, Literature, and Politics _is a fitting tribute to a man whose life’s work has been formed by commitment to the philosophical enterprise and by a conviction in Eric Voegelin’s contribution to that enterprise. The seventeen essays in this collection will be of particular interest to scholars of politics, comparative government, Japanese studies, political philosophy, and literary criticism. (shrink)